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PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

Name

Capella University

PSY FPX 6110 Learning Theories in Psychology

Prof. Name

Date

Annotated Bibliography

Davis, A. K., So, S., Lancelotta, R., Barsuglia, J. P., & Griffiths, R. R. (2019). 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety. The American Journal of Drug and Alcohol Abuse, 45(2), 161–169. https://doi.org/10.1080/00952990.2018.1545024

In 2019, Davis and colleagues investigated the effects of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) when used in a group setting, revealing notable decreases in depression and anxiety. The study centered on participants’ self-reported levels of depression and anxiety while using 5-MeO-DMT within a structured communal environment that included regulated dosing, established procedures, and supportive elements. Findings showed that 5-MeO-DMT use significantly alleviated symptoms of depression and anxiety. These positive outcomes were associated with an enhanced sense of spiritual importance and personal meaning gained from the experience.

Duerler, P., Schilbach, L., Stämpfli, P., Vollenweider, F. X., & Preller, K. H. (2020). LSD-induced increases in social adaptation to opinions similar to one’s own are associated with stimulation of serotonin receptors. Scientific Reports, 10(1), 12181. https://doi.org/10.1038/s41598-020-68899-y

Duerler et al. (2020) examined the influence of LSD on social adaptation to opinions that match one’s own, emphasizing the role of serotonin receptors in social influence processing. In a double-blind random crossover study involving 24 participants, individuals received either a placebo, LSD (100 micrograms), or a 5HT2A receptor antagonist plus LSD (100 micrograms) across three sessions. The study found that LSD significantly enhanced social adaptation, particularly when participants encountered opinions aligned with their own. This effect was associated with increased activity in the ventral medial prefrontal cortex during social feedback processing, offering insights into the neuropharmacological mechanisms of social cognitive behavior.

Forstmann, M., Yudkin, D. A., Prosser, A. M., Heller, S. M., & Crockett, M. J. (2020). Transformative experience and social connectedness mediate the mood-enhancing effects of psychedelic use in naturalistic settings. Proceedings of the National Academy of Sciences, 117(5), 2338–2346. https://doi.org/10.1073/pnas.1918477117

Forstmann et al. (2020) investigated the roles of transformative experiences and social connectedness in the mood-enhancing effects of psilocybin and other psychedelics in naturalistic settings. The three-year study included 1,225 participants across various mass gatherings, utilizing field studies and questionnaires. The findings suggested that recent psychedelic use was linked to increased transformative experiences and social connectedness, which mediated improvements in positive mood. This study highlights the potential of psychedelics to facilitate personal transformation and enhance social cohesion in naturalistic environments, with ethical approval from the Oxford Central Research Ethics Committee.

Griffiths, R. R., Johnson, M. W., Carducci, M. A., Umbricht, A., Richards, W. A., Richards, B. D., Cosimano, M. P., & Klinedinst, M. A. (2016). Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Journal of Psychopharmacology (Oxford), 30(12), 1181–1197. https://doi.org/10.1177/0269881116675513

In their 2016 study, Griffiths and colleagues examined how psilocybin affected depression and anxiety among cancer patients using a randomized double-blind trial. They recruited 51 patients facing life-threatening cancer diagnoses and gave them either a low or high dose of psilocybin in a crossover format. The findings revealed noteworthy decreases in depression and anxiety after administering the high dose of psilocybin, coupled with heightened senses of life’s meaning and optimism. These positive effects endured even six months later, suggesting that psilocybin could be a promising therapy for alleviating psychological distress in individuals with cancer.

Mitchell, J. M., Bogenschutz, M., Lilienstein, A., Harrison, C., Kleiman, S., Parker-Guilbert, K., Ot’alora G, M., Garas, W., Paleos, C., Gorman, I., Nicholas, C., Mithoefer, M., Carlin, S., Poulter, B., Mithoefer, A., Quevedo, S., Wells, G., Klaire, S. S., van der Kolk, B., Tzarfaty, K., … Doblin, R. (2021). MDMA-assisted therapy for severe PTSD: A randomized, double-blind, placebo-controlled phase 3 study. Nature Medicine, 27(6), 1025–1033. https://doi.org/10.1038/s41591-021-01336-3

In a study led by Mitchell and colleagues (2021), a phase 3 trial was carried out to assess the effectiveness and safety of using MDMA-assisted therapy to treat severe PTSD. Ninety individuals took part, randomly divided to receive either MDMA therapy or a placebo, along with preparatory and integrative sessions. Results revealed notable decreases in PTSD symptoms among those in the MDMA group compared to the placebo group, with some even experiencing remission after just one or two sessions. These findings highlight the promising role of MDMA-assisted therapy in addressing severe PTSD, indicating the need for additional clinical exploration.

PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

References

Davis, A. K., So, S., Lancelotta, R., Barsuglia, J. P., & Griffiths, R. R. (2019). 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety. The American Journal of Drug and Alcohol Abuse, 45(2), 161–169. https://doi.org/10.1080/00952990.2018.1545024

Duerler, P., Schilbach, L., Stämpfli, P., Vollenweider, F. X., & Preller, K. H. (2020). LSD-induced increases in social adaptation to opinions similar to one’s own are associated with stimulation of serotonin receptors. Scientific Reports, 10(1), 12181. https://doi.org/10.1038/s41598-020-68899-y

Forstmann, M., Yudkin, D. A., Prosser, A. M., Heller, S. M., & Crockett, M. J. (2020). Transformative experience and social connectedness mediate the mood-enhancing effects of psychedelic use in naturalistic settings. Proceedings of the National Academy of Sciences, 117(5), 2338–2346. https://doi.org/10.1073/pnas.1918477117

Griffiths, R. R., Johnson, M. W., Carducci, M. A., Umbricht, A., Richards, W. A., Richards, B. D., Cosimano, M. P., & Klinedinst, M. A. (2016). Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Journal of Psychopharmacology (Oxford), 30(12), 1181–1197. https://doi.org/10.1177/0269881116675513

PSY FPX 6110 Assessment 1 Annotated Bibliography-Psychedelic Therapy Studies

Mitchell, J. M., Bogenschutz, M., Lilienstein, A., Harrison, C., Kleiman, S., Parker-Guilbert, K., Ot’alora G, M., Garas, W., Paleos, C., Gorman, I., Nicholas, C., Mithoefer, M., Carlin, S., Poulter, B., Mithoefer, A., Quevedo, S., Wells, G., Klaire, S. S., van der Kolk, B., Tzarfaty, K., … Doblin, R. (2021). MDMA-assisted therapy for severe PTSD: A randomized, double-blind, placebo-controlled phase 3 study. Nature Medicine, 27(6), 1025–1033. https://doi.org/10.1038/s41591-021-01336-3



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